PDCD5 anticorps (N-Term)

N° du produit ABIN6991062

Cet anticorps anti-PDCD5 est un anticorps Lapin Polyclonal détectant PDCD5 dans WB, ELISA et ICC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour PDCD5 anticorps (N-Term) (ABIN6991062)

Antigène: PDCD5 (Programmed Cell Death 5 (PDCD5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDCD5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-PDCD5 anticorps

Épitope: N-Term

Purification: PDCD5 Antibody is affinity chromatography purified via peptide column.

Immunogène: PDCD5 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5.

Isotype: IgG

Information d'application

Indications d'application: PDCD5 antibody can be used for detection of PDCD5 by Western blot at 2.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PDCD5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur PDCD5

Antigène: PDCD5 (Programmed Cell Death 5 (PDCD5))

Autre désignation: PDCD5

Sujet: PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Poids moléculaire: Predicted: 14 kDa

Observed: 21 kDa

ID gène: 27347

UniProt: Q9UEW8